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The Pathogenesis of Chronic Lymphocytic Leukemia

29 Aug 2013

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is characterized by the clonal expansion of CD5(+)CD23(+) B cells in blood, marrow, and second lymphoid tissues. Gene-expression profiling and phenotypic studies suggest that CLL is probably derived from CD5(+) B cells similar to those found in the blood of healthy adults. Next-generation sequencing has revealed recurrent genetic lesions that are implicated in CLL pathogenesis...

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PMID: 23987584
DOI: 10.1146/annurev-pathol-020712-163955

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