Article
Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients.
Journal of translational medicine - 20 Jun 2018
De Matteis Serena, Molinari Chiara, Abbati Giulia, Rossi Tania, Napolitano Roberta, Ghetti Martina, Di Rorà Andrea Ghelli Luserna, Musuraca Gerardo, Lucchesi Alessandro, Rigolin Gian Matteo, Cuneo Antonio, Calistri Daniele, Fattori Pier Paolo, Bonafè Massimiliano, Martinelli Giovanni
Abstract excerpt
BACKGROUND: In chronic lymphocytic leukemia (CLL) disease onset and progression are influenced by the behavior of specific CD4+ T cell subsets, such as T regulatory cells (Tregs). Here, we focused on the phenotypic and functional characterization of Tregs in CLL patients to improve our understanding of the putative mechanism by which these cells combine immunosuppressive and effector-like properties. METHODS:...
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