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Article

A tumorigenic actin mutant alters fibroblast morphology and multicellular assembly properties.

Cytoskeleton (Hoboken, N.J.) - 1 Oct 2013

Blache Ulrich, Silván Unai, Plodinec Marija, Suetterlin Rosmarie, Jakob Roman, Klebba Ina, Bentires-Alj Mohamed, Aebi Ueli, Schoenenberger Cora-Ann

Abstract excerpt

Tumor initiation and progression are accompanied by complex changes in the cytoarchitecture that at the cellular level involve remodeling of the cytoskeleton. We report on the impact of a mutant β-actin (G245D-actin) on cell structure and multicellular assembly properties. To appreciate the effects of the Gly245Asp substitution on the organization of the actin cytoskeleton, we examined the polymerization...

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PMID: 23804571
DOI: 10.1002/cm.21120

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