Article
Depletion of the actin bundling protein SM22/transgelin increases actin dynamics and enhances the tumourigenic phenotypes of cells.
BMC cell biology - 18 Jan 2012
Thompson Oliver, Moghraby Jeelan S, Ayscough Kathryn R, Winder Steve J
Abstract excerpt
BACKGROUND: SM22 has long been studied as an actin-associated protein. Interestingly, levels of SM22 are often reduced in tumour cell lines, while they are increased during senescence possibly indicating a role for SM22 in cell fate decisions via its interaction with actin. In this study we aimed to determine whether reducing levels of SM22 could actively contribute to a tumourigenic phenotype. RESULTS: We...
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