Article
Alpha5 and alpha2 integrin gene transfers mimic the PDGF-B-induced transformed phenotype of fibroblasts in human skin.
Laboratory investigation; a journal of technical methods and pathology - 1 Sept 2001
Nesbit M, Schaider H, Berking C, Shih D T, Hsu M Y, McBrian M, Crombleholme T M, Elenitsas R, Buck C, Herlyn M
Abstract excerpt
Platelet-derived growth factor (PDGF)-B is a proto-oncogene capable of transforming fibroblasts. Using adenoviral vectors, we tested whether endogenous PDGF-B expression in human skin xenotransplants leads to changes in the expression of alpha5 and alpha2 integrin subunits and whether integrin overexpression leads to PDGF-related changes in the skin. In vitro, transduction of fibroblasts with PDGF-B or the...
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