Article
Morphological heterogeneity and phenotypical instability versus metastatic stability in the murine tumor model ER 15-P.
Journal of cancer research and clinical oncology - 1 Jan 1992
Edel G, Roessner A, Deneke B, Wörmann B
Abstract excerpt
At clinical presentation, the majority of malignant tumors are composed of multiple clonal subpopulations of tumor cells with different phenotypic characteristics. Using the experimental tumor model ER 15-P, a methylcholanthrene-induced pleomorphic sarcoma of the C57 Bl6J mouse, we studied a system of long-term in vivo passages of this primary tumor for cell morphological changes, and alterations in the potential...
Topics
- Actins
- Animals
- Disease Models, Animal
- Female
- Fibrosarcoma
- Keratins
- Lung Neoplasms
- Mice
- Mice, Inbred C57BL
- Neoplasm Metastasis
- Phenotype
- Sarcoma, Experimental