A quantitative comparison of human HT-1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotype.

doi:10.1371/journal.pone.0081689

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Article

A quantitative comparison of human HT-1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotype.

PloS one - 1 Jan 2013

Schwartz Michael P, Rogers Robert E, Singh Samir P, Lee Justin Y, Loveland Samuel G, Koepsel Justin T, Witze Eric S, Montanez-Sauri Sara I, Sung Kyung E, Tokuda Emi Y, Sharma Yasha, Everhart Lydia M, Nguyen Eric H, Zaman Muhammad H, Beebe David J, Ahn Natalie G, Murphy William L, Anseth Kristi S

Abstract excerpt

Here, we describe an engineering approach to quantitatively compare migration, morphologies, and adhesion for tumorigenic human fibrosarcoma cells (HT-1080s) and primary human dermal fibroblasts (hDFs) with the aim of identifying distinguishing properties of the transformed phenotype. Relative adhesiveness was quantified using self-assembled monolayer (SAM) arrays and proteolytic 3-dimensional (3D) migration was...

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PMID: 24349113
DOI: 10.1371/journal.pone.0081689
PMCID: PMC3857815

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