Article
Mutations at residues Tyr771 and Tyr783 of phospholipase C-gamma1 have different effects on cell actin-cytoskeleton organization and cell proliferation in CCL-39 cells.
FEBS letters - 13 Feb 1998
Pei Z D, Williamson J R
Abstract excerpt
Currently a central question that remains unresolved is the potential importance of phospholipase C (PLC)-gamma1 in cell mitogenesis. In this study, we introduced wild-type PLC-gamma1 plasmid and mutants Y771F and Y783F into CCL-39 fibroblasts and investigated their effect on host cell functions....
Topics
- Actins
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Division
- Cell Line
- Cricetinae
- Cricetulus
- Cytoskeleton
- Fibroblasts
- Isoenzymes
- Mitogen-Activated Protein Kinase 1
- Morphogenesis
- Mutation
- Phospholipase C gamma
- Phosphotyrosine
- Type C Phospholipases
- Tyrosine