Article
Structural plasticity of functional actin: pictures of actin binding protein and polymer interfaces.
Structure (London, England : 1993) - 1 Oct 2003
Rommelaere Heidi, Waterschoot Davy, Neirynck Katrien, Vandekerckhove Joël, Ampe Christophe
Abstract excerpt
Actin is one of the most conserved and versatile proteins capable of forming homopolymers and interacting with numerous other proteins in the cell. We performed an alanine mutagenesis scan covering the entire beta-actin molecule. Somewhat surprisingly, the majority of the mutants were capable of reaching a stable conformation. We tested the ability of these mutants to bind to various actin binding proteins,...
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