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Article

The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease.

Genome research - 1 Sept 2013

Case Laure K, Wall Emma H, Dragon Julie A, Saligrama Naresha, Krementsov Dimitry N, Moussawi Mohamad, Zachary James F, Huber Sally A, Blankenhorn Elizabeth P, Teuscher Cory

Abstract excerpt

Understanding the DNA elements that constitute and control the regulatory genome is critical for the appropriate therapeutic management of complex diseases. Here, using chromosome Y (ChrY) consomic mouse strains on the C57BL/6J (B6) background, we show that susceptibility to two diverse animal models of autoimmune disease, experimental allergic encephalomyelitis (EAE) and experimental myocarditis, correlates with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23800453
DOI: 10.1101/gr.156703.113
PMCID: PMC3759723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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