Article
Region-based association analysis of human quantitative traits in related individuals.
PloS one - 1 Jan 2013
Belonogova Nadezhda M, Svishcheva Gulnara R, van Duijn Cornelia M, Aulchenko Yurii S, Axenovich Tatiana I
Abstract excerpt
Regional-based association analysis instead of individual testing of each SNP was introduced in genome-wide association studies to increase the power of gene mapping, especially for rare genetic variants. For regional association tests, the kernel machine-based regression approach was recently proposed as a more powerful alternative to collapsing-based methods. However, the vast majority of existing algorithms...
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