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Article

Genome-wide discovery for biomarkers using quantile regression at biobank scale.

Nature communications - 31 Jul 2024

Wang Chen, Wang Tianying, Kiryluk Krzysztof, Wei Ying, Aschard Hugues, Ionita-Laza Iuliana

Abstract excerpt

Genome-wide association studies (GWAS) for biomarkers important for clinical phenotypes can lead to clinically relevant discoveries. Conventional GWAS for quantitative traits are based on simplified regression models modeling the conditional mean of a phenotype as a linear function of genotype. We draw attention here to an alternative, lesser known approach, namely quantile regression that naturally extends...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39085219
DOI: 10.1038/s41467-024-50726-x
PMCID: PMC11291931

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