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Article

Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila.

PLoS pathogens - 1 Feb 2011

Fontana Mary F, Banga Simran, Barry Kevin C, Shen Xihui, Tan Yunhao, Luo Zhao-Qing, Vance Russell E

Abstract excerpt

The intracellular bacterial pathogen Legionella pneumophila causes an inflammatory pneumonia called Legionnaires' Disease. For virulence, L. pneumophila requires a Dot/Icm type IV secretion system that translocates bacterial effectors to the host cytosol. L. pneumophila lacking the Dot/Icm system is recognized by Toll-like receptors (TLRs), leading to a canonical NF-κB-dependent transcriptional response. In...

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Identifiers

PMID: 21390206
DOI: 10.1371/journal.ppat.1001289
PMCID: PMC3040669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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