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Article

The Passage of Chaperonins to Extracellular Locations in Legionella pneumophila Requires a Functional Dot/Icm System.

Biomolecules - 9 Jan 2025

Robertson Peter, Allan David S, Garduño Rafael A

Abstract excerpt

HtpB, the chaperonin of the bacterial pathogen L. pneumophila, is found in extracellular locations, even the cytoplasm of host cells. Although chaperonins have an essential cytoplasmic function in protein folding, HtpB exits the cytoplasm to perform extracellular virulence-related functions that support L. pneumophila's lifestyle. The mechanism by which HtpB reaches extracellular locations is not currently...

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PMID: 39858485
DOI: 10.3390/biom15010091
PMCID: PMC11763710

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