Article
Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Biochemistry - 24 Nov 1998
Xia W, Zhang J, Ostaszewski B L, Kimberly W T, Seubert P, Koo E H, Shen J, Selkoe D J
Abstract excerpt
Progressive cerebral deposition of the amyloid beta-protein (Abeta) is believed to play a pivotal role in the pathogenesis of Alzheimer's disease (AD). The highly amyloidogenic 42-residue form of Abeta (Abeta42) is the first species to be deposited in both sporadic and familial AD. Mutations in t...
Topics
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Brain
- CHO Cells
- Cells, Cultured
- Cricetinae
- Endoplasmic Reticulum
- Golgi Apparatus
- Intracellular Fluid
- Kidney
- Macromolecular Substances
- Membrane Proteins
- Mice