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Article

Transcriptional regulation of the presenilin-1 gene: implication in Alzheimer's disease.

Frontiers in bioscience : a journal and virtual library - 1 Jan 2008

Das Hriday K

Abstract excerpt

Two (amyloid and presenilin) hypotheses have been proposed to explain the pathogenesis of Alzheimer's disease (AD). According to amyloid hypothesis, the main amyloid plaques which are hallmark of AD are generated by beta- and gamma-secretase mediated proteolytic processing of amyloid precursor protein (APP). The amyloid hypothesis does not adequately address the pathogenesis of the disease, however, since...

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Source

Identifiers

PMID: 17981591
DOI: 10.2741/2723

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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