Article
Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.
Nature cell biology - 1 Dec 2000
Sato N, Urano F, Yoon Leem J, Kim S H, Li M, Donoviel D, Bernstein A, Lee A S, Ron D, Veselits M L, Sisodia S S, Thinakaran G
Abstract excerpt
Presenilin 1 (PS1), a polytopic membrane protein, has a critical role in the trafficking and proteolysis of a selected set of transmembrane proteins. The vast majority of individuals affected with early onset familial Alzheimer's disease (FAD) carry missense mutations in PS1. Two studies have suggested that loss of PS1 function, or expression of FAD-linked PS1 variants, compromises the mammalian unfolded-protein...
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