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Article

Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

Journal of neuroscience research - 1 Jan 2007

Kuzuya Akira, Uemura Kengo, Kitagawa Naoyuki, Aoyagi Nobuhisa, Kihara Takeshi, Ninomiya Haruaki, Ishiura Shoichi, Takahashi Ryosuke, Shimohama Shun

Abstract excerpt

One of the pathologic hallmarks of Alzheimer's disease is the excessive deposition of beta-amyloid peptides (Abeta) in senile plaques. Abeta is generated when beta-amyloid precursor protein (APP) is cleaved sequentially by beta-secretase, identified as beta-site APP-cleaving enzyme 1 (BACE1), and...

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Source

Identifiers

PMID: 17075903
DOI: 10.1002/jnr.21104

Genes

BACE1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17075903-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).PMID 17075903Read ↗

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Mutant presenilin 1 increases the expression and activity of BACE1.Semantic proximity Read ↗

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Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation.Semantic proximity Read ↗

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Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.Semantic proximity Read ↗

Presenilin 1 Regulates Membrane Homeostatic Pathways that are Dysregulated in Alzheimer’s DiseaseSemantic proximity Read ↗

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