Article
Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations.
Cellular and molecular life sciences : CMLS - 1 Sept 1998
Kovacs D M, Tanzi R E
Abstract excerpt
Presenilin-1 (PS1) mutations account for the greatest portion of early onset familial Alzheimer's disease (FAD) cases. The exact cellular function of PS1 is not known. To date, PS1 mutations have been shown to alter two potential biological roles of the protein, either of which could make neurons...
Topics
- Age of Onset
- Alzheimer Disease
- Amyloid beta-Peptides
- Animals
- Apolipoproteins E
- Caenorhabditis elegans Proteins
- Cell Line
- Gene Expression
- Helminth Proteins
- Humans
- Membrane Proteins
- Mice
- Mice, Transgenic
- Middle Aged
- Mutation
- Nerve Degeneration
- Peptide Fragments
- Phenotype