Article
Mutant presenilin 1 increases the expression and activity of BACE1.
The Journal of biological chemistry - 3 Apr 2009
Giliberto Luca, Borghi Roberta, Piccini Alessandra, Mangerini Rosa, Sorbi Sandro, Cirmena Gabriella, Garuti Anna, Ghetti Bernardino, Tagliavini Fabrizio, Mughal Mohamed R, Mattson Mark P, Zhu Xiongwei, Wang Xinglong, Guglielmotto Michela, Tamagno Elena, Tabaton Massimo
Abstract excerpt
Mutations of the presenilin 1 (PS1) gene are the most common cause of early onset familial Alzheimer disease (FAD). PS1 mutations alter the activity of the gamma-secretase on the beta-amyloid precursor protein (APP), leading to selective overproduction of beta-amyloid (Abeta) 42 peptides, the species that forms oligomers that may exert toxic effects on neurons. Here we show that PS1 mutations, expressed both...
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