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Article

Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts.

American journal of physiology. Heart and circulatory physiology - 15 Aug 2013

Branovets Jelena, Sepp Mervi, Kotlyarova Svetlana, Jepihhina Natalja, Sokolova Niina, Aksentijevic Dunja, Lygate Craig A, Neubauer Stefan, Vendelin Marko, Birkedal Rikke

Abstract excerpt

Disruption of the creatine kinase (CK) system in hearts of CK-deficient mice leads to changes in the ultrastructure and regulation of mitochondrial respiration. We expected to see similar changes in creatine-deficient mice, which lack the enzyme guanidinoacetate methyltransferase (GAMT) to produce creatine. The aim of this study was to characterize the changes in cardiomyocyte mitochondrial organization,...

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Identifiers

PMID: 23792673
DOI: 10.1152/ajpheart.00919.2012
PMCID: PMC3891243

Genes

GAMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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