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Article

Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background.

Journal of molecular and cellular cardiology - 1 Jan 2009

Lygate Craig A, Hunyor Imre, Medway Debra, de Bono Joe P, Dawson Dana, Wallis Julie, Sebag-Montefiore Liam, Neubauer Stefan

Abstract excerpt

UNLABELLED: Discrepant results for the phenotype of mitochondrial creatine kinase knockout mice (Mt-CK(-/-)) could be due to mixed genetic background and use of non-littermate controls. We therefore backcrossed with C57BL/6J for >8 generations, followed by extensive in vivo cardiac phenotyping. Echocardiography and in vivo LV haemodynamics were performed in independent cohorts at 20-40 weeks and 1 year. No...

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Source

Identifiers

PMID: 18948110
DOI: 10.1016/j.yjmcc.2008.09.710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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