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Article

Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine.

Cardiovascular research - 1 Mar 2018

Faller Kiterie M E, Atzler Dorothee, McAndrew Debra J, Zervou Sevasti, Whittington Hannah J, Simon Jillian N, Aksentijevic Dunja, Ten Hove Michiel, Choe Chi-Un, Isbrandt Dirk, Casadei Barbara, Schneider Jurgen E, Neubauer Stefan, Lygate Craig A

Abstract excerpt

AIMS: Creatine buffers cellular adenosine triphosphate (ATP) via the creatine kinase reaction. Creatine levels are reduced in heart failure, but their contribution to pathophysiology is unclear. Arginine:glycine amidinotransferase (AGAT) in the kidney catalyses both the first step in creatine biosynthesis as well as homoarginine (HA) synthesis. AGAT-/- mice fed a creatine-free diet have a whole body...

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Identifiers

PMID: 29236952
DOI: 10.1093/cvr/cvx242
PMCID: PMC5982714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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