Article
Energetic crosstalk between organelles: architectural integration of energy production and utilization.
Circulation research - 20 Jul 2001
Kaasik A, Veksler V, Boehm E, Novotova M, Minajeva A, Ventura-Clapier R
Abstract excerpt
Cells with high and fluctuating energy demands such as cardiomyocytes need efficient systems to link energy production to energy utilization. This is achieved in part by compartmentalized energy transfer enzymes such as creatine kinase (CK). However, hearts from CK-deficient mice develop normal cardiac function under conditions of moderate workload. We have therefore investigated whether a direct functional...
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