Article
Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies.
Cell - 4 Apr 1997
Steeghs K, Benders A, Oerlemans F, de Haan A, Heerschap A, Ruitenbeek W, Jost C, van Deursen J, Perryman B, Pette D, Brückwilder M, Koudijs J, Jap P, Veerkamp J, Wieringa B
Abstract excerpt
We have blocked creatine kinase (CK)-mediated phosphocreatine (PCr) -->/<-- ATP transphosphorylation in skeletal muscle by combining targeted mutations in the genes encoding mitochondrial and cytosolic CK in mice. Contrary to expectation, the PCr level was only marginally affected, but the compound was rendered metabolically inert. Mutant muscles in vivo showed significantly impaired tetanic force output,...
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