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In vivo 2D mapping of impaired murine cardiac energetics in NO‐induced heart failure

30 Nov 2006

Abstract excerpt

(31)P MRS studies in humans have shown that an impairment of cardiac energetics is characteristic of heart failure. Although numerous transgenic mouse models with a heart-failure phenotype have been generated, current methods to analyze murine high-energy phosphates (HEPs) in vivo are hampered by limited spatial resolution. Using acquisition-weighted 2D (31)P chemical shift imaging (CSI) at 9.4 Tesla, we were...

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PMID: 17139621
DOI: 10.1002/mrm.21101

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