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Article

In vivo induction of lymphokine-activated killer cells by interleukin-2 splenic artery perfusion in advanced malignancy.

Cancer research - 15 Aug 1990

Klasa R J, Silver H K, Kong S

Abstract excerpt

In an effort to stimulate in vivo LAK cell activity at relatively nontoxic doses, 20 patients with advanced metastatic malignancy (13 renal cell carcinoma, 6 melanoma, 1 lymphoma) were treated with recombinant human interleukin-2 (IL-2) by continuous 5-day splenic artery perfusion using the femoral approach. Two treatment cycles were administered 3 weeks apart; IL-2 doses ranged from 1.5-4 x 10(4) Cetus...

Topics

Antigens, CD
Cytotoxicity, Immunologic
Drug Evaluation
HLA-DR Antigens
Humans
Interleukin-2
Killer Cells, Lymphokine-Activated
Killer Cells, Natural
Leukocyte Count
Neoplasms
Perfusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Splenic Artery

Source

Identifiers

PMID: 2379154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2379154-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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