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Article

Regulatory effects of interleukin-4 on tumor-infiltrating lymphocytes derived from human renal cell carcinoma.

The Journal of surgical research - 1 Dec 1992

Peyret C, Bochner B H, Lee T Y, Koo A S, deKernion J B, Belldegrun A

Abstract excerpt

We have studied the effects of interleukin-4 (IL-4) on the expansion, proliferation, phenotype, and antitumor activity of tumor-infiltrating lymphocytes (TIL) derived from human renal cell carcinoma. Cultures were obtained from three primary renal tumors and one group of tumor-invaded, regional lymph nodes. IL-4 induced a significant increase in lymphocyte expansion and proliferation, but the response was...

Topics

Carcinoma, Renal Cell
Cell Division
Cytotoxicity, Immunologic
Dose-Response Relationship, Drug
Humans
Interleukin-2
Interleukin-4
Kidney Neoplasms
Lymphocytes, Tumor-Infiltrating
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 1494294
DOI: 10.1016/0022-4804(92)90261-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1494294-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Regulatory effects of interleukin-4 on tumor-infiltrating lymphocytes derived from human renal cell carcinoma.PMID 1494294Read ↗

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