Article
In vivo treatment with interferon causes augmentation of IL-2 induced lymphokine-activated killer cells in the organs of mice.
Clinical and experimental immunology - 1 Aug 1991
Puri R K, Leland P
Abstract excerpt
Interferon-alpha (IFN-alpha) has been shown to synergize with IL-2 in the regression of a variety of established murine tumours and studies are underway to explore this combination in patients with advanced cancers as well. To understand the mechanism of synergy we have studied lymphokine-activat...
Topics
- Animals
- Drug Synergism
- Female
- Fluorescent Antibody Technique
- Interferons
- Interleukin-2
- Interleukin-4
- Killer Cells, Lymphokine-Activated
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Phenotype
- Recombinant Proteins
- Tumor Necrosis Factor-alpha