Clinical trials of intrasplenic arterial infusion of interleukin-2 (IS-IL-2) to patients with advanced cancer.

doi:10.1007/BF02172655

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Article

Clinical trials of intrasplenic arterial infusion of interleukin-2 (IS-IL-2) to patients with advanced cancer.

Biotherapy (Dordrecht, Netherlands) - 1 Jan 1992

Okuno K, Ohnishi H, Koh K, Shindo H, Yoshioka H, Yasutomi M

Abstract excerpt

We tried a infusion of interleukin-2 (IL-2) of a relatively low dose via an intrasplenic arterial catheter connected to a chronometric infusion (IS-IL-2). Eighteen patients of colorectal cancer with metastases to the liver or lung or of unresectable hepatoma received a 24 hour continuous infusion...

Topics

Aged
Cohort Studies
Dose-Response Relationship, Drug
Humans
Infusions, Intra-Arterial
Interleukin-2
Killer Cells, Lymphokine-Activated
Killer Cells, Natural
Leukocyte Count
Leukocytes, Mononuclear
Liver Neoplasms
Lung Neoplasms
Lymphocyte Activation
Lymphocytes
Male
Middle Aged
Neoplasms
Phenotype

Source

Open in PubMed

Identifiers

PMID: 1622739
DOI: 10.1007/BF02172655

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1622739-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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