Article
Interferon-alpha primed tumor-infiltrating lymphocytes combined with interleukin-2 and interferon-alpha as therapy for metastatic renal cell carcinoma.
The Journal of urology - 1 Nov 1993
Belldegrun A, Pierce W, Kaboo R, Tso C L, Shau H, Turcillo P, Moldawer N, Golub S, deKernion J, Figlin R
Abstract excerpt
Murine models demonstrate therapeutic synergy for the combination of interleukin-2, interferon-alpha and tumor-infiltrating lymphocytes. We treated 11 patients with metastatic renal cell carcinoma with a novel regimen consisting of in vivo primed tumor-infiltrating lymphocytes, interferon-alpha a...
Topics
- Adult
- Aged
- Antigens, CD
- Carcinoma, Renal Cell
- Cells, Cultured
- Combined Modality Therapy
- Cytotoxicity, Immunologic
- Female
- Humans
- Immunotherapy, Adoptive
- Interferon-alpha
- Interleukin-2
- Kidney Neoplasms
- Lymphocytes, Tumor-Infiltrating