Article
Solid-phase anti-CD3 antibody activation of murine tumor-infiltrating lymphocytes.
Cancer research - 1 May 1990
Massaro A F, Schoof D D, Rubinstein A, Zuber M, Leonard-Vidal F J, Eberlein T J
Abstract excerpt
Seventeen consecutive s.c. murine tumors, derived from a sarcoma and a colon adenocarcinoma, were cultured in the presence of recombinant interleukin 2 (rIL-2) for growth of tumor-infiltrating lymphocytes (TIL). Identical cultures were activated by solid-phase monoclonal antibody directed against the murine CD3 epsilon-chain, in conjunction with rIL-2. Forty-eight h later, cells were replaced in rIL-2 alone....
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
- CD3 Complex
- Cells, Cultured
- Cytotoxicity, Immunologic
- Female
- Interleukin-2
- Lung Neoplasms
- Lymphocyte Activation
- Mice