Article
Liver sequestration of murine lymphokine activated killer (LAK) cells is mediated by carbohydrate-specific receptors.
Regional immunology - 1 Jan 2000
Samlowski W E, McGregor J R, Litton G J
Abstract excerpt
Intravenous infusion of radiolabeled lymphokine activated killer (LAK) cells into tumor bearing humans and animals results in retention of a large percentage (40-70%) of cells within the liver. Since LAK cell-tumor cell adhesion is believed to be necessary to initiate effective cytotoxicity, liver sequestration may decrease the therapeutic effectiveness of the adoptively transferred cells. We evaluated the...
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