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Article

Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation

1 Nov 2011

Abstract excerpt

High expression of the mitotic kinase Bub1 is associated with a variety of human cancers and correlates with poor clinical prognosis, but whether Bub1 alone can drive tumorigenesis was unknown. We provided conclusive evidence that Bub1 has oncogenic properties by generating transgenic mice that overexpress Bub1 in a wide variety of tissues, resulting in aneuploidization. Consistently, Bub1 transgenic mice...

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PMID: 22033440
DOI: 10.4161/cc.10.21.18156

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