Article
SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores.
Nature communications - 3 Oct 2016
Li Teng, Chen Liang, Cheng Juanxian, Dai Jiang, Huang Yijiao, Zhang Jian, Liu Zhaoshan, Li Ang, Li Na, Wang Hongxia, Yin Xiaomin, He Kun, Yu Ming, Zhou Tao, Zhang Xuemin, Xia Qing
Abstract excerpt
Chromosome alignment is required for accurate chromosome segregation. Chromosome misalignment can result in genomic instability and tumorigenesis. Here, we show that NF-κB activating protein (NKAP) is critical for chromosome alignment through anchoring CENP-E to kinetochores. NKAP knockdown causes chromosome misalignment and prometaphase arrest in human cells. NKAP dynamically localizes to kinetochores, and is...
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