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Article

Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.

The Journal of cell biology - 22 Jul 2013

Park Inai, Lee Hae-ock, Choi Eunhee, Lee Yoo-Kyung, Kwon Mi-Sun, Min Jaewon, Park Pil-Gu, Lee Seonju, Kong Young-Yun, Gong Gyungyub, Lee Hyunsook

Abstract excerpt

BubR1 acetylation is essential in mitosis. Mice heterozygous for the acetylation-deficient BubR1 allele (K243R/+) spontaneously developed tumors with massive chromosome missegregations. K243R/+ mouse embryonic fibroblasts (MEFs) exhibited a weakened spindle assembly checkpoint (SAC) with shortened mitotic timing. The generation of the SAC signal was intact, as Mad2 localization to the unattached kinetochore (KT)...

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Identifiers

PMID: 23878276
DOI: 10.1083/jcb.201210099
PMCID: PMC3718975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.PMID 23878276Read ↗

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