Article
Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.
The Journal of cell biology - 22 Jul 2013
Park Inai, Lee Hae-ock, Choi Eunhee, Lee Yoo-Kyung, Kwon Mi-Sun, Min Jaewon, Park Pil-Gu, Lee Seonju, Kong Young-Yun, Gong Gyungyub, Lee Hyunsook
Abstract excerpt
BubR1 acetylation is essential in mitosis. Mice heterozygous for the acetylation-deficient BubR1 allele (K243R/+) spontaneously developed tumors with massive chromosome missegregations. K243R/+ mouse embryonic fibroblasts (MEFs) exhibited a weakened spindle assembly checkpoint (SAC) with shortene...
Topics
- Acetylation
- Alleles
- Aneuploidy
- Animals
- Aurora Kinase B
- Aurora Kinases
- Cell Cycle Proteins
- Cell Transformation, Neoplastic
- Chromosomes, Mammalian
- Embryonic Development
- Genomic Instability
- Heterozygote
- Kinetochores
- M Phase Cell Cycle Checkpoints