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Article

Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function.

Circulation - 1 May 2007

Lillie Elizabeth O, Mahata Manjula, Khandrika Srikrishna, Rao Fangwen, Bundey Richard A, Wen Gen, Chen Yuqing, Taupenot Laurent, Smith Douglas W, Mahata Sushil K, Ziegler Michael G, Cockburn Myles, Schork Nicholas J, O'Connor Daniel T

Abstract excerpt

BACKGROUND: Endothelial dysfunction predisposes to vascular injury in association with hypertension. Endothelin (ET-1) is a potent vasoactive peptide that is synthesized and released by the vascular endothelium and is a marker of endothelial function. Chromogranin A (CHGA) regulates the storage a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17438153
DOI: 10.1161/CIRCULATIONAHA.106.648345

Genes

CHGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17438153-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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