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Article

Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans.

Circulation - 29 Jan 2008

Fung Maple M, Nguyen Carie, Mehtani Parag, Salem Rany M, Perez Brandon, Thomas Brenda, Das Madhusudan, Schork Nicholas J, Mahata Sushil K, Ziegler Michael G, O'Connor Daniel T

Abstract excerpt

BACKGROUND: Catecholamines govern stress blood pressure responses. Catecholaminergic responses may be partially genetic and contribute to the complex heritability of hypertension. METHODS AND RESULTS: To evaluate catecholaminergic responses without systemic counterregulation, we infused graded concentrations of tyramine, an indirect presynaptic norepinephrine releaser, into dorsal hand veins of 49 normotensive...

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Source

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Identifiers

PMID: 18180394
DOI: 10.1161/CIRCULATIONAHA.107.706317
PMCID: PMC2628716

Genes

CHGB
FMO3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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