Article
Increased cell wall teichoic acid production and D-alanylation are common phenotypes among daptomycin-resistant methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates.
PloS one - 1 Jan 2013
Bertsche Ute, Yang Soo-Jin, Kuehner Daniel, Wanner Stefanie, Mishra Nagendra N, Roth Tobias, Nega Mulugeta, Schneider Alexander, Mayer Christoph, Grau Timo, Bayer Arnold S, Weidenmaier Christopher
Abstract excerpt
Multiple mechanisms have been correlated with daptomycin-resistance (DAP-R) in Staphylococcus aureus. However, one common phenotype observed in many DAP-R S. Aureus strains is a thickened cell wall (CW). The first evidence for an impact of CW-linked glycopolymers on this phenotype was recently demonstrated in a single, well-characterized DAP-R methicillin-susceptible S. aureus (MSSA) strain. In this isolate the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.