Article
Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy - 1 Jun 2009
Mishra Nagendra N, Yang Soo-Jin, Sawa Ayumi, Rubio Aileen, Nast Cynthia C, Yeaman Michael R, Bayer Arnold S
Abstract excerpt
Our previous studies of clinical daptomycin-resistant (Dap(r)) Staphylococcus aureus strains suggested that resistance is linked to the perturbations of several key cell membrane (CM) characteristics, including the CM order (fluidity), phospholipid content and asymmetry, and relative surface charge. In the present study, we examined the CM profiles of a well-known methicillin-resistant Staphylococcus aureus...
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