Article
Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanisms.
Antimicrobial agents and chemotherapy - 1 Aug 2010
Yang Soo-Jin, Nast Cynthia C, Mishra Nagendra N, Yeaman Michael R, Fey Paul D, Bayer Arnold S
Abstract excerpt
The mechanism(s) of daptomycin (DAP) resistance (DAPr) is incompletely defined. Thickened cell walls (CWs) acting as either a mechanical barrier or an affinity trap for DAP have been purported to be a major contributor to the DAPr phenotype. To this end, we studied an isogenic set of methicillin-resistant Staphylococcus aureus (MRSA) isolates (pulsotype USA 300) from the bloodstream of a DAP-treated patient with...
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