Article

Comprehensive Analysis of PIK3CA Mutations in Advanced Colorectal Cancer Using Circulating Tumor DNA Profiling

2024-12-18

Abstract excerpt

<title>Abstract</title> <p>Mutations in PIK3CA are prevalent in advanced colorectal cancer (CRC) and are associated with advanced-stage disease and poor prognosis. However, the prognostic value of these mutations remains unclear. In order to better understand their role in CRC progression, we evaluated the genomic landscape of PIK3CA mutations (PIK3CAm) in advanced CRC using plasma-based ctDNA from ~17,000 sample...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d256f7ae-6ce1-53a3-a85e-fb44922590f6
DOI: 10.21203/rs.3.rs-5162348/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comprehensive Analysis of PIK3CA Mutations in Advanced Colorectal Cancer Using Circulating Tumor DNA ProfilingDOI 10.21203/rs.3.rs-5162348/v1Read

The Landscape of PIK3CA Mutations in Colorectal Cancer.Semantic proximity Read

Molecular characteristics of advanced colorectal cancer and multi-hit PIK3CA mutations.Semantic proximity Read

KRAS mutated colorectal cancers with or without PIK3CA mutations: Clinical and molecular profiles inform current and future therapeutics.Semantic proximity Read

Prognostic and Predictive Value of Circulating Tumor DNA in Patients with Advanced Colorectal Cancer and ChemotherapySemantic proximity Read

KRAS, APC, and TP53 mutations define opposing immune archetypes in stage III colorectal cancerSemantic proximity Read

The potential of PIK3CA, KRAS, BRAF, and APC hotspot mutations as a non-invasive detection method for colorectal cancer.Semantic proximity Read

[Detection of PIK3CA gene mutation and its related prognosis in colorectal cancer based on next-generation sequencing].Semantic proximity Read

Impact of Chemotherapy Exposure and DNMT3A Variants on Tumor Mutation Burden in Advanced Colorectal CancerSemantic proximity Read

Incidence of RSPO3 rearrangements in advanced colorectal cancer patients detected by NGS and their relationship with disease characteristicsSemantic proximity Read

PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival.Semantic proximity Read

PIK3CA Somatic Mutation Status in Relation to Patient and Tumor Factors in Racial/Ethnic Minorities with Colorectal Cancer.Semantic proximity Read

Deep Next Generation Sequencing Identifies Somatic Mutational Signature in Egyptian Colorectal Cancer PatientsSemantic proximity Read