Article
PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations.
Neoplasia (New York, N.Y.) - 1 Jun 2008
Nosho Katsuhiko, Kawasaki Takako, Ohnishi Mutsuko, Suemoto Yuko, Kirkner Gregory J, Zepf Dimity, Yan Liying, Longtine Janina A, Fuchs Charles S, Ogino Shuji
Abstract excerpt
Somatic PIK3CA mutations are often present in colorectal cancer. Mutant PIK3CA activates AKT signaling, which up-regulates fatty acid synthase (FASN). Microsatellite instability (MSI) and CpG island methylator phenotype (CIMP) are important molecular classifiers in colorectal cancer. However, the relationship between PIK3CA mutation, MSI and CIMP remains uncertain. Using Pyrosequencing technology, we detected...
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