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Article

Selective modulation of the functions of a conserved DNA motor by a histone fold complex.

Genes & development - 15 May 2015

Xue Xiaoyu, Choi Koyi, Bonner Jacob N, Szakal Barnabas, Chen Yu-Hung, Papusha Alma, Saro Dorina, Niu Hengyao, Ira Grzegorz, Branzei Dana, Sung Patrick, Zhao Xiaolan

Abstract excerpt

Budding yeast Mph1 helicase and its orthologs drive multiple DNA transactions. Elucidating the mechanisms that regulate these motor proteins is central to understanding genome maintenance processes. Here, we show that the conserved histone fold MHF complex promotes Mph1-mediated repair of damaged replication forks but does not influence the outcome of DNA double-strand break repair. Mechanistically, scMHF...

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Share to DEAD-box RNA Helicases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25956905
DOI: 10.1101/gad.259143.115
PMCID: PMC4441048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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