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Article

Genetic evidence for a role of Saccharomyces cerevisiae Mph1 in recombinational DNA repair under replicative stress.

Yeast (Chichester, England) - 1 Jan 2010

Panico Evandro Rocco, Ede Christopher, Schildmann Michael, Schürer Kirsten Anke, Kramer Wilfried

Abstract excerpt

In yeast as in human, DNA helicases play critical roles in assisting replication fork progression. The Saccharomyces cerevisiae MPH1 gene, homologue of human FANCM, has been involved in homologous recombination and DNA repair. We describe a synthetic growth defect of an mph1 deletion if combined...

Read the complete abstract on PubMed

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Share to DEAD-box RNA Helicases
Share to DNA Helicases
Share to DNA, Recombinant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to DNA Replication

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Share to Gene Expression Regulation, Fungal

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Source

Identifiers

PMID: 19918932
DOI: 10.1002/yea.1727

Genes

FANCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19918932-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence for a role of Saccharomyces cerevisiae Mph1 in recombinational DNA repair under replicative stress.PMID 19918932Read ↗

Budding yeast Mph1 promotes sister chromatid interactions by a mechanism involving strand invasion.Semantic proximity Read ↗

Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination.Semantic proximity Read ↗

Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase.Semantic proximity Read ↗

Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair.Semantic proximity Read ↗

DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of Smc6 mutants.Semantic proximity Read ↗

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.Semantic proximity Read ↗

Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.Semantic proximity Read ↗

Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover.Semantic proximity Read ↗

Genetic and physical interactions between Schizosaccharomyces pombe Mcl1 and Rad2, Dna2 and DNA polymerase alpha: evidence for a multifunctional role of Mcl1 in DNA replication and repair.Semantic proximity Read ↗

The budding yeast protein Chl1p is required to preserve genome integrity upon DNA damage in S-phase.Semantic proximity Read ↗

Mph1 requires mismatch repair-independent and -dependent functions of MutSalpha to regulate crossover formation during homologous recombination repair.Semantic proximity Read ↗

Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.Semantic proximity Read ↗

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