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Pyrimidine motif triple helix in the <i>Kluyveromyces lactis</i> telomerase RNA pseudoknot is essential for function in vivo

17 Jun 2013

Abstract excerpt

Telomerase is a ribonucleoprotein complex that extends the 3' ends of linear chromosomes. The specialized telomerase reverse transcriptase requires a multidomain RNA (telomerase RNA, TER), which includes an integral RNA template and functionally important template-adjacent pseudoknot. The structure of the human TER pseudoknot revealed that the loops interact with the stems to form a triple helix shown to be...

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PMID: 23776224
DOI: 10.1073/pnas.1309590110

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Pyrimidine motif triple helix in the <i>Kluyveromyces lactis</i> telomerase RNA pseudoknot is essential for function in vivoPMID 23776224Read ↗

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