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Article

A critical three-way junction is conserved in budding yeast and vertebrate telomerase RNAs.

Nucleic acids research - 1 Jan 2007

Brown Yogev, Abraham Mira, Pearl Sivan, Kabaha Majdi M, Elboher Elhanan, Tzfati Yehuda

Abstract excerpt

The telomerase ribonucleoprotein copies a short template within its integral RNA moiety onto eukaryotic chromosome ends, compensating for incomplete replication and degradation. Non-template regions of telomerase RNA (TER) are also crucial for telomerase function, yet they are highly divergent in sequence among species and their roles are largely unclear. Using both phylogenetic and mutational analyses, we...

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Identifiers

PMID: 17855392
DOI: 10.1093/nar/gkm713
PMCID: PMC2094081

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A critical three-way junction is conserved in budding yeast and vertebrate telomerase RNAs.PMID 17855392Read ↗

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