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The conserved structure of plant telomerase RNA provides the missing link for an evolutionary pathway from ciliates to humans

21 Nov 2019

Abstract excerpt

Telomerase is essential for maintaining telomere integrity. Although telomerase function is widely conserved, the integral telomerase RNA (TR) that provides a template for telomeric DNA synthesis has diverged dramatically. Nevertheless, TR molecules retain 2 highly conserved structural domains critical for catalysis: a template-proximal pseudoknot (PK) structure and a downstream stem-loop structure. Here we...

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PMID: 31754031
DOI: 10.1073/pnas.1915312116

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