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Article

A triple helix within a pseudoknot is a conserved and essential element of telomerase RNA.

Molecular and cellular biology - 1 Mar 2007

Shefer Kinneret, Brown Yogev, Gorkovoy Valentin, Nussbaum Tamar, Ulyanov Nikolai B, Tzfati Yehuda

Abstract excerpt

Telomerase copies a short template within its integral telomerase RNA onto eukaryotic chromosome ends, compensating for incomplete replication and degradation. Telomerase action extends the proliferative potential of cells, and thus it is implicated in cancer and aging. Nontemplate regions of telomerase RNA are also crucial for telomerase function. However, they are highly divergent in sequence among species, and...

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Identifiers

PMID: 17210648
DOI: 10.1128/MCB.01826-06
PMCID: PMC1820488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A triple helix within a pseudoknot is a conserved and essential element of telomerase RNA.PMID 17210648Read ↗

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Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function.Semantic proximity Read ↗

Refined secondary-structure models of the core of yeast and human telomerase RNAs directed by SHAPESemantic proximity Read ↗

Functional analysis of the pseudoknot structure in human telomerase RNA.Semantic proximity Read ↗

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An intermolecular RNA triplex provides insight into structural determinants for the pseudoknot stimulator of -1 ribosomal frameshifting.Semantic proximity Read ↗

Functional importance of telomerase pseudoknot revealed by single-molecule analysis.Semantic proximity Read ↗

Comprehensive structure-function analysis of the core domain of human telomerase RNA.Semantic proximity Read ↗

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A 4-base pair core-enclosing helix in telomerase RNA is essential and binds to the TERT catalytic protein subunitSemantic proximity Read ↗

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