Article
The -1195G allele increases the transcriptional activity of cyclooxygenase-2 gene (COX-2) in colon cancer cell lines.
Molecular carcinogenesis - 1 Feb 2014
Pereira Carina, Sousa Hugo, Silva Joana, Brandão Carla, Elgueta-Karstegl Claudio, Farrell Paul J, Medeiros Rui, Dinis-Ribeiro Mário
Abstract excerpt
Up-regulation of cyclooxygenase-2 (COX-2) is an early and key event in human colorectal carcinogenesis (CRC). Nevertheless, the molecular mechanisms leading to this over-expression are largely unknown. We previously reported an association between the -1195G allele and higher predisposition for CRC in a Caucasian population. The biological explanation for the involvement of this polymorphism in CRC remains...
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